Cloned (Comment) | Organism |
---|---|
expression in Drosophila S2 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-3 | recombinant human inhibitor protein from Escherichia coli, i.e. tissue inhibitor of metalloproteinases, strong inhibitor with regulatory function | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | metalloproteinase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | Homo sapiens | degradation of cartilage matrix | ? | - |
? | |
proteins + H2O | Homo sapiens | - |
peptides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aggrecan + H2O | cleavage site is Glu373-Ala374 | Homo sapiens | ? | - |
? | |
aggrecan + H2O | degradation of cartilage matrix | Homo sapiens | ? | - |
? | |
proteins + H2O | - |
Homo sapiens | peptides | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAM-TS5 | - |
Homo sapiens |
aggrecanase-2 | - |
Homo sapiens |
M12.225 | Merops-ID | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000066 | - |
TIMP-3 | pH 7.5, 37°C | Homo sapiens |