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Literature summary for 3.4.24.B10 extracted from

  • Roy, R.; Wewer, U.M.; Zurakowski, D.; Pories, S.E.; Moses, M.A.
    ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage (2004), J. Biol. Chem., 279, 51323-51330.
    View publication on PubMed
Search for more literature for 3.4.24.B10

Application

Application Comment Organism
medicine implication in Alzheimer's disease, arthritis, and cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in COS-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline total inhibition when incubated with gelatin at 37 °C for either 2 or 18 h Homo sapiens
EDTA total inhibition when incubated with gelatin at 37 °C for either 2 or 18 h Homo sapiens
endogenous matrix metalloprotease inhibitor 500 nM, TIMP-3 Homo sapiens
marimastat 1 mM, partial inhibition when incubated with gelatin at 37 °C for either 2 or 18 h Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
68000
-
 SDS-PAGE, mature form of ADAM 12 Homo sapiens
120000
-
 non-denaturing SDS-PAGE, full-length ADAM 12-L Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Q-Sepharose anion exchange and gelatin-Sepharose affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fibronectin + H2O
-
 Homo sapiens ?
-
 ?
Gelatin + H2O
-
 Homo sapiens ?
-
 ?
Type IV collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM 12 a disintegrin and metalloprotease 12 Homo sapiens
full-length ADAM 12-S
-
 Homo sapiens