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Literature summary for 3.4.24.B10 extracted from

  • Cao, Y.; Zhao, Z.; Gruszczynska-Biegala, J.; Zolkiewska, A.
    Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro (2003), Mol. Cell. Biol., 23, 6725-6738.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B10

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest Mus musculus

Protein Variants

Protein Variants Comment Organism
L73P mutant with properties similar to wild-type concerning the cell cycle of C2C12 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
small interfering RNA inhibits expression of the enzyme in C2C12 cells Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metalloprotease domain is not essential for inhibition of cell cycle progression by the enzyme Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation ?
-
 ?
protein + H2O Mus musculus
-
 peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell myoblast cell line Mus musculus
-
myoblast cell culture, reserve cells, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts Mus musculus
-
myotube low content in the multinucleated cells Mus musculus
-
skeletal muscle myoblast Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information overexpression in C2C12 cells, leading to upregulation of retinoblastoma-related proteins p130, cell cycle inhibitor protein p27, and the differentiation markers myogenin and integrin alpha7A isoform, all resulting in cell cycle arrest, enzyme induces a quiescence-like phenotype and does not stimulate differentiation in myoblasts, enzyme mediated adhesion or signaling may play a role in determination of the pool of reserve cells during myoblast differentiation Mus musculus ?
-
 ?
protein + H2O
-
 Mus musculus peptides
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin and metalloprotease-12
-
 Mus musculus
ADAM12
-
 Mus musculus
M12.212 Merops-ID Mus musculus
metalloprotease-disintegrin ADAM12
-
 Mus musculus