Any feedback?
Literature summary for 3.4.24.87 extracted from
- ADAMTS-13: Double trouble for von Willebrand factor (2010), J. Thromb. Haemost., 8, 2775-2777.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | Homo sapiens | ADAMTS-13 has thiol reductase activity limited towards von Willebrand factor | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| von Willebrand factor + H2O | ADAMTS-13 has thiol reductase activity limited towards von Willebrand factor | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS-13 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAMTS-13 cleaves von Willebrand factor into smaller fragments via cleavage in the VWF A2-domain, making VWF less reactive towards platelets. ADAMTS-13 is the regulator of von Willebrand factor activity | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
