Literature summary for 3.4.24.87 extracted from

Rossi, F.C.; Angerami, R.N.; de Paula, E.V.; Orsi, F.L.; Shang, D.; del Guercio, V.M.; Resende, M.R.; Annichino-Bizzacchi, J.M.; da Silva, L.J.; Zheng, X.L.; Castro, V.
A novel association of acquired ADAMTS13 inhibitor and acute dengue virus infection (2010), Transfusion, 50, 208-212.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
ADAMTS13	-	Homo sapiens

General Information

General Information	Comment	Organism
additional information	antibody formation against ADAMTS13, as ADAMTS13 inhibitor, in the course of a severe acute Dengue virus infection results in thrombotic microangiopathy. Anti-ADAMTS13 inhibitor disappears after remission of thrombotic microangiopathy and dengue resolution. No recurrence of thrombotic microangiopathy symptoms after 2-year follow-up. Thrombotic microangiopathy is a severe occlusive microvascular thrombotic syndrome characterized by profound thrombocytopenia, microangiopathic hemolytic anemia, and symptoms of organ ischemia. Thrombotic microangiopathy includes primarily two syndromes, thrombotic thrombocytopenic purpura and hemolytic uremic syndrome	Homo sapiens
physiological function	ADAMTS13 deficiency plays a central role in the pathogenesis of hereditary or acquired idiopathic thrombotic thrombocytopenic purpura	Homo sapiens

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Release 2023.1 (January 2023)