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Literature summary for 3.4.24.87 extracted from

  • Lerolle, N.; Dunois-Larde, C.; Badirou, I.; Motto, D.G.; Hill, G.; Bruneval, P.; Diehl, J.L.; Denis, C.V.; Baruch, D.
    von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture (2009), J. Thromb. Haemost., 7, 843-850.
    View publication on PubMed
Search for more literature for 3.4.24.87

Inhibitors

Inhibitors Comment Organism Structure
additional information ADAMTS-13 activity is evaluated in a model of sepsis induced by cecum ligature and puncture in wild-type and Vwf-/- mice. In wild-type mice, cecum ligature and puncture-induced sepsis elicits a significant ADAMTS-13 decrease, and a strong negative correlation exists between von Willebrand factor, VWF, and ADAMTS-13. In Vwf-/- mice, cecum ligature and puncture also induces severe sepsis, but ADAMTS-13 is not significantly diminished Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-13
-
 Mus musculus

General Information

General Information Comment Organism
additional information ADAMTS-13 activity is evaluated in a model of sepsis induced by cecum ligature and puncture in wild-type and Vwf-/- mice. In wild-type mice, cecum ligature and puncture-induced sepsis elicits a significant ADAMTS-13 decrease, and a strong negative correlation exists between von Willebrand factor, VWF, and ADAMTS-13. In Vwf-/- mice, cecum ligature and puncture also induces severe sepsis, but ADAMTS-13 is not significantly diminished Mus musculus
physiological function antithrombotic properties of ADAMTS-13, complete ADAMTS-13 deficiency promotes thrombus formation and embolization in activated murine microvenule endothelium Mus musculus