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Literature summary for 3.4.24.87 extracted from

  • Varadi, K.; Rottensteiner, H.; Vejda, S.; Weber, A.; Muchitsch, E.M.; Turecek, P.L.; Ehrlich, H.J.; Scheiflinger, F.; Schwarz, H.P.
    Species-dependent variability of ADAMTS13-mediated proteolysis of human recombinant von Willebrand factor (2009), J. Thromb. Haemost., 7, 1134-1142.
    View publication on PubMed
Search for more literature for 3.4.24.87

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Cavia porcellus
-
-
extracellular
-
 Mus musculus
-
-
extracellular
-
 Homo sapiens
-
-
extracellular
-
 Rattus norvegicus
-
-
extracellular
-
 Sus scrofa
-
-
extracellular
-
 Oryctolagus cuniculus
-
-
extracellular
-
 Canis lupus familiaris
-
-
extracellular
-
 Macaca fascicularis
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ activates Cavia porcellus
Ba2+ activates Mus musculus
Ba2+ activates Homo sapiens
Ba2+ activates Rattus norvegicus
Ba2+ activates Sus scrofa
Ba2+ activates Oryctolagus cuniculus
Ba2+ activates Canis lupus familiaris
Ba2+ activates Macaca fascicularis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Cavia porcellus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O Mus musculus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O Homo sapiens ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O Rattus norvegicus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O Sus scrofa ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O Oryctolagus cuniculus ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O Canis lupus familiaris ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O Macaca fascicularis ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
 beagle dogs
-
Cavia porcellus
-
 Dunkin Hartley guinea pigs
-
Homo sapiens
-
-
-
Macaca fascicularis
-
 cynomolgus monkey
-
Mus musculus
-
 wild-type strain C57BL/6J mice, the isogenic von Willebrand factor-deficient strain 129x1/SvJ, and the ADAMTS13-deficient gene knock-out strain CAST/EiJ
-
Oryctolagus cuniculus
-
 New Zealand white rabbits
-
Rattus norvegicus
-
 Sprague-Dawley rats
-
Sus scrofa
-
 Yorkshire strain
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Cavia porcellus
-
plasma
-
 Mus musculus
-
plasma
-
 Homo sapiens
-
plasma
-
 Rattus norvegicus
-
plasma
-
 Sus scrofa
-
plasma
-
 Oryctolagus cuniculus
-
plasma
-
 Canis lupus familiaris
-
plasma
-
 Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Cavia porcellus ?
-
 ?
additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Homo sapiens ?
-
 ?
additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Rattus norvegicus ?
-
 ?
additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Sus scrofa ?
-
 ?
additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Oryctolagus cuniculus ?
-
 ?
additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Canis lupus familiaris ?
-
 ?
additional information differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Macaca fascicularis ?
-
 ?
additional information no activity in von Willebrand factor-deficient or ADAMTS13-deficient mice with the recombinant substrate of human origin. Differences in susceptibility to cleavage of recombinant von Willebrand factor by different species need to be considered when interpreting the physiology of human recombinant von Willebrand factor from results of tests in animal models Mus musculus ?
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Cavia porcellus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Mus musculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Rattus norvegicus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Sus scrofa von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Oryctolagus cuniculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Canis lupus familiaris von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain Macaca fascicularis von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Macaca fascicularis von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Comparison of the activity with human recombinan substrate in vitro with enzymes from other mammal enzymes, overview Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The guinea pig ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Cavia porcellus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The rabbit ADAMTS13 shows activity similar to the human ADAMTS13 with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Oryctolagus cuniculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The rat ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Rattus norvegicus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. The wild-type mouse ADAMTS13 shows no activity with the recombinant human substrate in vitro, comparison to other mammal enzymes, overview Mus musculus von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Very low activity with recombinant human substrate in vitro, comparison to other mammal enzymes, overview Sus scrofa von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?
von Willebrand factor + H2O ADAMTS13 cleaves von Willebrand factor at the Tyr1605-Met1606 bond within the central A2 domain. Very low activity with recombinant human substrate in vitro, comparison to other mammal enzymes, overview Canis lupus familiaris von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS13
-
 Cavia porcellus
ADAMTS13
-
 Mus musculus
ADAMTS13
-
 Homo sapiens
ADAMTS13
-
 Rattus norvegicus
ADAMTS13
-
 Sus scrofa
ADAMTS13
-
 Oryctolagus cuniculus
ADAMTS13
-
 Canis lupus familiaris
ADAMTS13
-
 Macaca fascicularis
plasma metalloprotease ADAMTS13
-
 Cavia porcellus
plasma metalloprotease ADAMTS13
-
 Mus musculus
plasma metalloprotease ADAMTS13
-
 Homo sapiens
plasma metalloprotease ADAMTS13
-
 Rattus norvegicus
plasma metalloprotease ADAMTS13
-
 Sus scrofa
plasma metalloprotease ADAMTS13
-
 Oryctolagus cuniculus
plasma metalloprotease ADAMTS13
-
 Canis lupus familiaris
plasma metalloprotease ADAMTS13
-
 Macaca fascicularis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Cavia porcellus
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens
37
-
 assay at Rattus norvegicus
37
-
 assay at Sus scrofa
37
-
 assay at Oryctolagus cuniculus
37
-
 assay at Canis lupus familiaris
37
-
 assay at Macaca fascicularis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Cavia porcellus
8
-
 assay at Mus musculus
8
-
 assay at Homo sapiens
8
-
 assay at Rattus norvegicus
8
-
 assay at Sus scrofa
8
-
 assay at Oryctolagus cuniculus
8
-
 assay at Canis lupus familiaris
8
-
 assay at Macaca fascicularis