Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | substrate modified by alpha2-3,6,8,9-neuraminidase from Arthrobacter ureafaciens removing alpha2-3- and alpha2-6-linked sialic acid results in reduced ADAMTS13 activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable expression in HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | substrate modified by treatment with PNGase F to remove complex N-linked glycan structures results in increased ADAMTS13 activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
von Willebrand factor + H2O | - |
Homo sapiens | ? | - |
? | |
von Willebrand factor + H2O | wild-type plasma-derived substrate of human origin, and substrate modified by alpha2-3,6,8,9-neuraminidase from Arthrobacter ureafaciens removing alpha2-3- and alpha2-6-linked sialic acid, and treatment with PNGase F to remove complex N-linked glycan structures. alpha2-6-linked sialic acid increases von Willebrand factor proteolysis by ADAMTS13 through a conformational mechanism, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS13 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |