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Literature summary for 3.4.24.87 extracted from

  • Turner, N.A.; Nolasco, L.; Ruggeri, Z.M.; Moake, J.L.
    Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage (2009), Blood, 114, 5102-5111.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information specific blockade of von Willebrand factor string cleavage by antibody to ADAMTS-13, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular ADAMTS-13 is released directly from the Golgi to the cell exterior without an organelle storage site, e.g. a cytoplasmic granule Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens
Zn2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens ADAMTS-13 cleavage of von Willebrand factor strings secreted from stimulated and unstimulated HUVECs occurs at the position 1605-6 of the von Willebrand factor A2 domain von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell obtained from collagenase-digested human umbilical veins, ADAMTS-13 is released directly from the Golgi to the cell exterior without an organelle storage site, e.g. a cytoplasmic granule Homo sapiens
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plasma
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
more ADAMTS-13-mediated cleavage of the relatively few von Willebrand factor strings secreted at a slow rate from unstimulated HUVECs, and less ADAMTS-13 cleavage of the many von Willebrand factor strings secreted rapidly in response to cell stimulation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
von Willebrand factor + H2O ADAMTS-13 cleavage of von Willebrand factor strings secreted from stimulated and unstimulated HUVECs occurs at the position 1605-6 of the von Willebrand factor A2 domain Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?
von Willebrand factor + H2O ADAMTS-13 cleavage of HUVEC-secreted von Willebrand factor strings at Y1605-6M sites of the von Willebrand factor A2 domain Homo sapiens von Willebrand factor 140-kD fragment + von Willebrand factor 176-kD fragment
-
?

Synonyms

Synonyms Comment Organism
ADAMTS-13
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Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens