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Literature summary for 3.4.24.87 extracted from

  • Moriki, T.; Maruyama, I.N.; Igari, A.; Ikeda, Y.; Murata, M.
    Identification of ADAMTS13 peptide sequences binding to von Willebrand factor (2010), Biochem. Biophys. Res. Commun., 391, 783-788.
    View publication on PubMed
Search for more literature for 3.4.24.87

Cloned(Commentary)

Cloned (Comment) Organism
construction of ADAMTS13 epitope library Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information construction and screening of an epitope peptide library, e.g. of epitope-A, i.e. a C-terminus of spacer domain from Arg670 to Gln684, and epitope-B, i.e. Pro618 to Glu641 in the middle of spacer domain. Synthetic epitope-B peptide inhibits the cleavage of VWF by ADAMTS13, while the synthetic epitope-A peptide does inhibit not as efficiently as epitope-B. Elimination of four amino acids from either sides of epitope-B terminus markedly reduces the inhibitory effect Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information structure-function analysis, overview Homo sapiens ?
-
 ?
von Willebrand factor + H2O
-
 Homo sapiens ?
-
 ?
von Willebrand factor + H2O identification of ADAMTS13 peptide sequences binding to von Willebrand factor, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS13
-
 Homo sapiens