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Literature summary for 3.4.24.87 extracted from

  • Wu, J.J.; Fujikawa, K.; McMullen, B.A.; Chung, D.W.
    Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor (2006), Proc. Natl. Acad. Sci. USA, 103, 18470-18474.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.87

Inhibitors

Inhibitors Comment Organism Structure
Pro-1645-Lys-1668 fragment of von Willebrand factor 73
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00025
-
 HRPH-A2-B
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
von Willebrand factor + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
HRPH-A2-B HRPH-A2-B is a derivative of von Willebrand factor 73, consisting of a HRP conjugate of a biotinylated von Willebrand factor 78 sequence Homo sapiens ? cleavage of Tyr842-Met843 within the A2 domain, i.e. Tyr1605-Met1606 in von Willebrand factor UniProt Id P04275 ?
von Willebrand factor + H2O
-
 Homo sapiens ?
-
 ?
von Willebrand factor 73 + H2O minimal substrate cleavable by ADAMTS-13 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-13
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.67
-
 HRPH-A2-B
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
 Pro-1645-Lys-1668 fragment of von Willebrand factor 73
-
 Homo sapiens