Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.86 extracted from

  • Pavlenko, E.; Cabron, A.; Arnold, P.; Dobert, J.; Rose-John, S.; Zunke, F.
    Functional characterization of colon cancer-associated mutations in ADAM17 Modifications in the pro-domain interfere with trafficking and maturation (2019), Int. J. Mol. Sci., 20, E2198 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.86

Protein Variants

Protein Variants Comment Organism
D616N the mutant reveals significantly lower activity with interleukin 6 receptor and normal shedding activity towards pro-TNFalpha compared to the wild type enzyme Homo sapiens
D657A the mutant reveals significantly lower activity with pro-TNFalpha and normal shedding activity towards interleukin 6 receptor compared to the wild type enzyme Homo sapiens
R177C R177C is a cancer-associated point mutation within the pro-domain of ADAM17 which is most impaired in its proteolytic activity and tracking to the cell membrane. The mutant enzyme shows greatly diminished shedding activity with pro-TNF-alpha and interleukin 6 receptor Homo sapiens
R725H the mutant reveals significantly lower activity with interleukin 6 receptor and normal shedding activity towards pro-TNFalpha compared to the wild type enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
interleukin 6 receptor + H2O Homo sapiens
-
 soluble interleukin 6 receptor + ?
-
 ?
pro-TNF-alpha + H2O Homo sapiens
-
 soluble TNF-alpha + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78536
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
interleukin 6 receptor + H2O
-
 Homo sapiens soluble interleukin 6 receptor + ?
-
 ?
pro-TNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 130000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADAM17
-
 Homo sapiens