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Literature summary for 3.4.24.86 extracted from

  • Li, W.; Wang, D.; Sun, X.; Zhang, Y.; Wang, L.; Suo, J.
    ADAM17 promotes lymph node metastasis in gastric cancer via activation of the Notch and Wnt signaling pathways (2019), Int. J. Mol. Med., 43, 914-926 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.86

Application

Application Comment Organism
medicine the enzyme is upregulated in gastric cancer cells with high metastatic potential Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-TNF-alpha + H2O Homo sapiens
-
 soluble TNF-alpha + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P78536
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
 Homo sapiens
-
BGC-823 cell
-
 Homo sapiens
-
gastric cancer cell
-
 Homo sapiens
-
KATO-III cell
-
 Homo sapiens
-
SGC-7901 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-TNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha + ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM17
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is significantly upregulated in gastric cancer and positive metastatic lymph node tissues up

General Information

General Information Comment Organism
physiological function the increased expression of the enzyme promotes the progression of gastric cancer, potentially via Notch and/or Wnt signaling pathway activation Homo sapiens