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Literature summary for 3.4.24.86 extracted from

  • Xu, J.; Sriramula, S.; Lazartigues, E.
    Excessive glutamate stimulation impairs ACE2 activity through ADAM17-mediated shedding in cultured cortical neurons (2018), Cell. Mol. Neurobiol., 38, 1235-1243 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
glutamate the shedding activity of the enzyme is increased during glutamate stimulation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
DPC333 specific inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin-converting enzyme type 2 + H2O Mus musculus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin-converting enzyme type 2 + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
ADAM17
-
Mus musculus
TNF converting enzyme
-
Mus musculus

General Information

General Information Comment Organism
metabolism the elevated activity of ADAM17 contributes to the glutamate-induced angiotensin-converting enzyme type 2 down-regulation Mus musculus