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Literature summary for 3.4.24.86 extracted from
- Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes (2016), Biochim. Biophys. Acta, 1863, 2795-2808 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GI254023X | - |
Homo sapiens |  |
| TAPI-1 | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| exosome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amphiregulin + H2O | Homo sapiens | - |
? | - |
? | |
| CX3CL1 + H2O | Homo sapiens | - |
? | - |
? | |
| interleukin-6 receptor + H2O | Homo sapiens | - |
? | - |
? | |
| junctional adhesion molecule A + H2O | Homo sapiens | - |
? | - |
? | |
| L-selectin + H2O | Homo sapiens | - |
? | - |
? | |
| syndecan-1 + H2O | Homo sapiens | - |
? | - |
? | |
| syndecan-4 + H2O | Homo sapiens | - |
? | - |
? | |
| TGFalpha + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P78536 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| HEK-293 cell | - |
Homo sapiens | - |
| HUVEC cell | - |
Homo sapiens | - |
| lung epithelial cell | - |
Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amphiregulin + H2O | - |
Homo sapiens | ? | - |
? | |
| CX3CL1 + H2O | - |
Homo sapiens | ? | - |
? | |
| interleukin-6 receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| junctional adhesion molecule A + H2O | - |
Homo sapiens | ? | - |
? | |
| L-selectin + H2O | - |
Homo sapiens | ? | - |
? | |
| syndecan-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| syndecan-4 + H2O | - |
Homo sapiens | ? | - |
? | |
| TGFalpha + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 100000, mature enzyme, SDS-PAGE | Homo sapiens |
| ? | x * 130000, proenzyme, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM17 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate leads to the downregulation of the surface expressed mature form of the enzyme | down |
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