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Literature summary for 3.4.24.86 extracted from

  • Chapnick, D.; Bunker, E.; Liu, X.
    A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation (2015), Sci. Signal., 8, 365.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cytochalasin D
-
Mus musculus
additional information actin cytoskeletal disruption causes endogenous activation of TACE and accumulation at the plasma membrane Mus musculus
additional information TACE activation by stimulating epithelial growth factor receptor occurs via p38/ERK Mus musculus
Quinacrine
-
Mus musculus

Application

Application Comment Organism
analysis development of a fluorescence resonance energy transfer-based biosensor that quantitatively reports the kinetics of TACE activity in live cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
doxorubicin
-
Mus musculus
sunitinib
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane actin cytoskeletal disruption causes endogenous activation of TACE and accumulation at the plasma membrane Mus musculus 5886
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z0F8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast embryonic fibroblast Mus musculus
-