Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P78536 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HUVEC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cell surface VEGF receptor Flt + H2O | - |
Homo sapiens | ? | release of an N-terminal extracellular fragment which can antagonize the effects of vascular endothelial growth factor | ? | |
cell surface VEGF receptor Flt + H2O | - |
Homo sapiens | ? | substrate can be cleaved to release an N-terminal extracellular fragment. Overexpression of ADAM10, EC 3.4.24.81, and ADAM17 increase cleavage while knockdown of ADAM10 and ADAM17 reduce N-terminal cleavage | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | overexpression of ADAM10 and ADAM17 increase cleavage of cell surface VEGF receptor Flt while knockdown of ADAM10 and ADAM17 reduce N-terminal cleavage suggesting that these metalloproteases are responsible for Flt1 cleavage | Homo sapiens |