Literature summary for 3.4.24.86 extracted from

Jing, Y.; Ni, Z.; Wu, J.; Higgins, L.; Markowski, T.; Kaufman, D.; Walcheck, B.
Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells (2015), PLoS ONE, 10, e121788.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P78536	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CD16 + H2O	substrates CD16a and CD16b are IgG Fc receptors expressed by human natural killer cells and neutrophils, respectively. Substrates contain three separate cleavage sites in close proximity at P1/P1' positions Ala195/Val196, Val196/Ser197, and Thr198/Ile199, revealing a membrane proximal cleavage region in CD16. Mutation S197P effectively blocks CD16a and CD16b cleavage in cell-based assays. Mutant CD16a/S197P is resistant to cleavage when expressed in cells. The S197P mutation does not disrupt IgG binding by the receptor or its activation of NK92 cells by antibody-treated tumor cells	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)