Literature summary for 3.4.24.86 extracted from

Lorenzen, I.; Lokau, J.; D�sterh�ft, S.; Trad, A.; Garbers, C.; Scheller, J.; Rose-John, S.; Gr�tzinger, J.
The membrane-proximal domain of A disintegrin and metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II (2012), FEBS Lett., 586, 1093-1100.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9Z0F8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
interleukin (IL)-1R-II + H2O	exclusively the extracellular domains of ADAM17 are needed for interaction with substrate, whereas the transmembrane- and cytoplasmic-region are dispensable for this process. In the extracellular part solely the membrane-proximal domain of ADAM17 is mandatory for recognition	Mus musculus	?	-	?
interleukin (IL)-6R + H2O	exclusively the extracellular domains of ADAM17 are needed for interaction with substrate, whereas the transmembrane- and cytoplasmic-region are dispensable for this process. In the extracellular part solely the membrane-proximal domain of ADAM17 is mandatory for recognition	Mus musculus	?	-	?
proTGF-alpha + H2O	the membrane-proximal domain in the extracellular part of ADAM17 is mandatory for recognition of the type-I transmembrane proteins, but not for the interaction with the type-II transmembrane molecule TNF-alpha	Mus musculus	soluble TGF-alpha	-	?

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Release 2023.1 (January 2023)