Literature summary for 3.4.24.86 extracted from

Feng, W.F.; Zhao, Y.B.; Huang, W.; Yang, Y.Z.
Molecular modeling and biological effects of peptidomimetic inhibitors of TACE activity (2009), J. Enzyme Inhib. Med. Chem., 25, 459-466.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking studies of inhibitor 2-(N-benzoxycarbonyl)aminoethyl-N-(4-hydroxyamino-4-oxo-2-(isopropylthio)butanoyl)-L-3-phenylalanyl-L-alanyl amide	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
N-[4-(hydroxyamino)-4-oxo-2-(phenylsulfanyl)butyl]-3-(naphthalen-2-yl)-L-alanyl-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-alaninamide	peptidomimetic inhibitor, 54.5% inhibition in in vitro lipopolysaccharide cytotoxicity tests, inhibitory activity in vivo by measuring the expression of mTNFalpha	Homo sapiens
N-[4-(hydroxyamino)-4-oxo-2-(phenylsulfanyl)butyl]-L-phenylalanyl-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-alaninamide	peptidomimetic inhibitor, 54.5% inhibition in in vitro lipopolysaccharide cytotoxicity tests	Homo sapiens
N-[4-(hydroxyamino)-4-oxo-2-(propan-2-ylsulfanyl)butyl]-L-phenylalanyl-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-alaninamide	peptidomimetic inhibitor, 27.3% inhibition in in vitro lipopolysaccharide cytotoxicity tests, molecular docking studies	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)