Activating Compound | Comment | Organism | Structure |
---|---|---|---|
granulocyte-macrophage colony-stimulating factor | granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor | Homo sapiens | |
interleukin-4 | granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
peripheral blood mononuclear cell | - |
Homo sapiens | - |
RPMI-8226 cell | - |
Homo sapiens | - |
U-266 cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor | up |
General Information | Comment | Organism |
---|---|---|
physiological function | granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of macrophage colony-stimulating factor M-CSF receptor, resulting in the disruption of its phosphorylation by M-CSF as well as the induction of osteoclastogenesis from monocytes by M-CSF and receptor activator of nuclear factor-kappaB RANK ligand. TACE inhibition robustly causes the resumption of the surface expression of M-CSF receptor on monocytes, facilitating M-CSF-mediated phosphorylation of M-CSF receptor and macrophage/osteoclast differentiation while impairing GM-CSF- and IL-4-mediated dendritic cell differentiation from monocytes | Homo sapiens |