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Literature summary for 3.4.24.86 extracted from
- The cytoplasmic domains of TNFalpha-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding (2010), Biochem. J., 428, 293-304.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| p38 mitogen-activated protein kinase | increased and sustained cell surface levels of TACE, and phosphorylation of its cytoplasmic tail, a hallmark of TACE activation, occur in lymphocytes and monocytes following p38 MAPK activation | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-selectin + H2O | TACE is involved in cantharidin-induced shedding of L-selectin. Cantharidin induces sustained surface expression and cytoplasmic tail phosphorylation of TACE via p38 MAPK, while L-selectin is involved in promoting protein kinase C-dependent shedding | Mus musculus | ? | - |
? |  |
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