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Literature summary for 3.4.24.86 extracted from

  • Bozkulak, E.C.; Weinmaster, G.
    Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling (2009), Mol. Cell. Biol., 29, 5679-5695.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.86

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
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 Mus musculus
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NIH-3T3 cell
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Notch1 + H2O Notch1 is a substrate for both ADAM10 and ADAM17 Mus musculus ?
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 ?

General Information

General Information Comment Organism
physiological function Notch1 signaling independent of ligands requires ADAM17, while ADAM10 is absolutely required for Notch1 signaling induced by ligands. Both proteases participate in signaling intrinsic to Notch mutations associated with leukemia Homo sapiens