Application | Comment | Organism |
---|---|---|
medicine | in this study the relationship between long-term alcohol consumption and the concentration of TACE in peripheral blood mononuclear cells and its substrate- soluble TNF-alpha receptor type 1 in plasma in psoriasis patients is analysed. The study is conducted among 44 patients (aged 30-59 years) with early-onset, plaque-type psoriasis. 38 patients (aged 29-61 years) with other than psoriasis chronic dermatologic disorders are controls. The data on alcohol consumption during previous 10 years are obtained with a structured questionnaire. The severity of the disease is assessed using Psoriasis Area and Severity Index (PASI), and concentrations of TACE in peripheral blood mononuclear cells lysate and soluble TNF-alpha receptor type 1 in plasma is assessed with a quantitative sandwich enzyme immunoassay technique. The alcohol abuse contributes to the increase of TACE expression in blood mononuclear cells and also to the elevated plasma soluble TNF-alpha receptor type 1 concentration in psoriasis patients | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
soluble TNF-alpha receptor type 1 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
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TACE | - |
Homo sapiens |