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Literature summary for 3.4.24.86 extracted from
- Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells (2007), J. Biol. Chem., 282, 33714-33724.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| oxygen | low oxygen concentrations enhance TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region | Rattus norvegicus |  |
| Tumor necrosis factor alpha | 20 ng/ml tumor necrosis factor alpha enhances TACE mRNA levels in synovial cells through direct binding of hypoxia-inducible factor-1 to the 5' promoter region | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| synovial cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| p75 tumour necrosis factor receptor + H2O | - |
Rattus norvegicus | ? | - |
? | |
| proTNF-alpha + H2O | - |
Rattus norvegicus | soluble TNF-alpha | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM17 | - |
Rattus norvegicus |
| TACE | - |
Rattus norvegicus |
| tumor necrosis factor-alpha converting enzyme | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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