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Literature summary for 3.4.24.86 extracted from

  • Chun, K.; Park, S.; Kim, H.M.; Choi, Y.; Kim, M.; Park, C.; Joe, B.; Chun, T.G.; Choi, H.; Lee, H.; Hong, S.H.; Kim, M.S.; Nam, K.; Han, G.
    Chromen-based TNF-alpha converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation (2008), Bioorg. Med. Chem., 16, 530-535.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-(6-methyl-2-oxo-2H-chromen-3-ylmethyl)-pent-4-enoic acid hydroxyamide
-
Homo sapiens
2-benzyl-N-hydroxy-3-(6-methyl-2-oxo-2H-chromen-3-yl)-propionamide
-
Homo sapiens
3-(6-bromo-2-oxo-2H-chromen-3-yl)-N-hydroxy-propanamide
-
Homo sapiens
3-(6-chloro-2-oxo-2H-chromen-3-yl)-N-hydroxy-propanamide
-
Homo sapiens
3-(6-tert-butyl-2-oxo-2H-chromen-3-yl)-N-hydroxypropanamide
-
Homo sapiens
gelastatin hydroxamate
-
Homo sapiens
N-hydroxy-2-((6-methoxy-2H-chromen-3-yl)methyl)propanamide
-
Homo sapiens
N-hydroxy-2-methyl-3-(6-methyl-2-oxo-2H-chromen-3-yl)-propionamide
-
Homo sapiens
N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide
-
Homo sapiens
N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl)propanamide
-
Homo sapiens
N-hydroxy-3-(6-methyl-2-oxo-2H-chromen-3-yl)propanamide
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)-acetyl-Pro-Leu-Ala-Gln-Ala-Val-[N-3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl]-Arg-Ser-Ser-Ser-Arg-NH2 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
TACE
-
Homo sapiens
TNF-alpha converting enzyme
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
at 25°C Homo sapiens N-hydroxy-2-methyl-3-(6-methyl-2-oxo-2H-chromen-3-yl)-propionamide
0.000005
-
at 25°C Homo sapiens 2-benzyl-N-hydroxy-3-(6-methyl-2-oxo-2H-chromen-3-yl)-propionamide
0.000028
-
at 25°C Homo sapiens gelastatin hydroxamate
0.00003
-
at 25°C Homo sapiens 2-(6-methyl-2-oxo-2H-chromen-3-ylmethyl)-pent-4-enoic acid hydroxyamide
0.000036
-
at 25°C Homo sapiens N-hydroxy-2-((6-methoxy-2H-chromen-3-yl)methyl)propanamide
0.00006
-
at 25°C Homo sapiens N-hydroxy-3-(6-methyl-2-oxo-2H-chromen-3-yl)propanamide
0.00011
-
at 25°C Homo sapiens N-hydroxy-3-(6-methoxy-2-oxo-2H-chromen-3-yl)propanamide
0.00015
-
at 25°C Homo sapiens N-hydroxy-3-(2-oxo-2H-chromen-3-yl)propanamide
0.00055
-
at 25°C Homo sapiens 3-(6-chloro-2-oxo-2H-chromen-3-yl)-N-hydroxy-propanamide
0.00084
-
at 25°C Homo sapiens 3-(6-bromo-2-oxo-2H-chromen-3-yl)-N-hydroxy-propanamide
0.0124
-
at 25°C Homo sapiens 3-(6-tert-butyl-2-oxo-2H-chromen-3-yl)-N-hydroxypropanamide