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Literature summary for 3.4.24.86 extracted from

  • Bergmeier, W.; Piffath, C.L.; Cheng, G.; Dole, V.S.; Zhang, Y.; von Andrian, U.H.; Wagner, D.D.
    Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIba shedding from platelets in vitro and in vivo (2004), Circ. Res., 95, 677-683.
    View publication on PubMed
Search for more literature for 3.4.24.86

Inhibitors

Inhibitors Comment Organism Structure
4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)-thiomorpholinecarboxamide IC50: 0.009 mM Homo sapiens
4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)-thiomorpholinecarboxamide IC50: 0.05 mM Mus musculus
N(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-alanine amide IC50: about 0.11 mM Homo sapiens
N(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-alanine amide IC50: about 0.7 mM Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycoprotein Ibalpha + H2O Mus musculus ADAM17 is the key enzyme mediating shedding of glycoprotein Ibalpha ?
-
 ?
glycoprotein Ibalpha + H2O Homo sapiens ADAM17 is the key enzyme mediating shedding of glycoprotein Ibalpha ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Mus musculus
-
blood platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycoprotein Ibalpha + H2O
-
 Mus musculus ?
-
 ?
glycoprotein Ibalpha + H2O
-
 Homo sapiens ?
-
 ?
glycoprotein Ibalpha + H2O ADAM17 is the key enzyme mediating shedding of glycoprotein Ibalpha Mus musculus ?
-
 ?
glycoprotein Ibalpha + H2O ADAM17 is the key enzyme mediating shedding of glycoprotein Ibalpha Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM17
-
 Mus musculus
ADAM17
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.009
-
 IC50: 0.009 mM Homo sapiens 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)-thiomorpholinecarboxamide
0.05
-
 IC50: 0.05 mM Mus musculus 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)-thiomorpholinecarboxamide
0.11
-
 IC50: about 0.11 mM Homo sapiens N(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-alanine amide
0.7
-
 IC50: about 0.7 mM Mus musculus N(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-alanine amide