Any feedback?
Literature summary for 3.4.24.86 extracted from
- Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) (2006), Bioorg. Med. Chem. Lett., 17, 266-271.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]acetamide | IC50: above 0.1 mM | Sus scrofa |  |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-(1,3,5-trioxo-2,4-diazaspiro[5.5]undec-7-yl)benzamide | IC50: 0.000138 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)benzamide | IC50: above 0.1 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-2-oxa-7,9-diazaspiro[4.5]dec-4-yl)benzamide | IC50: 0.000044 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-7,9-diazaspiro[4.5]dec-1-yl)benzamide | IC50: 0.000024 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-2-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide | - |
Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide | IC50: 0.000031 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[4-(pyridin-3-ylcarbonyl)piperazin-1-yl]hexahydropyrimidin-5-yl]methyl)benzamide | IC50: 0.00001 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[1-(methylsulfonyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide | IC50: 0.000029 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[4-(methylsulfonyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide | IC50: 0.000002 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-phenylhexahydropyrimidin-5-yl)methyl]benzamide | - |
Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-piperidin-4-ylhexahydropyrimidin-5-yl)methyl]benzamide | IC50: 0.000055 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)(pyridin-4-yl)methyl]benzamide | IC50: 0.00236 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]benzamide | IC50: 0.000026 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-[2-(methylsulfonyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide | IC50: 0.000036 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-[6,8,10-trioxo-2-(pyridin-3-ylcarbonyl)-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide | IC50: 0.000029 mM | Sus scrofa | |
| 4-[(2-methylquinolin-4-yl)methoxy]-N-[[2,4,6-trioxo-5-(4-phenylpiperazin-1-yl)hexahydropyrimidin-5-yl]methyl]benzamide | - |
Sus scrofa | |
| 5-methyl-5-(2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.049 mM | Sus scrofa | |
| 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-oxopropyl)pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.0008 mM | Sus scrofa | |
| 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.011 mM | Sus scrofa | |
| 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]propyl)pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: above 0.1 mM | Sus scrofa | |
| 5-methyl-5-[(2E)-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | - |
Sus scrofa | |
| 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.0022 mM | Sus scrofa | |
| 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.0013 mM | Sus scrofa | |
| 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | IC50: 0.00103 mM | Sus scrofa | |
| N-(2-acetyl-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000055 mM | Sus scrofa | |
| N-(8-acetyl-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undec-11-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | - |
Sus scrofa | |
| N-([5-[1-(1-methylethyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000052 mM | Sus scrofa | |
| N-([5-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000013 mM | Sus scrofa | |
| N-([5-[4-(1-methylethyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000007 mM | Sus scrofa | |
| N-([5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000029 mM | Sus scrofa | |
| N-([5-[4-(5-amino-8-carbamimidamido-4-oxooctyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | - |
Sus scrofa | |
| N-[(5-benzyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000018 mM | Sus scrofa | |
| N-[(5-ethyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000016 mM | Sus scrofa | |
| N-[2-(2,2-dimethylpropanoyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000111 mM | Sus scrofa | |
| N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)acetamide | IC50: 0.012 mM | Sus scrofa | |
| N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)propanamide | - |
Sus scrofa | |
| N-[[5-(1-methylethyl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000019 mM | Sus scrofa | |
| N-[[5-(1-methylpiperidin-4-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000057 mM | Sus scrofa | |
| N-[[5-(4-acetylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000005 mM | Sus scrofa | |
| N-[[5-(4-benzylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000014 mM | Sus scrofa | |
| N-[[5-(4-ethynylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000062 mM | Sus scrofa | |
| N-[[5-(4-methylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | IC50: 0.000058 mM | Sus scrofa | |
| tert-butyl (5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)carbamate | IC50: 0.000013 mM | Sus scrofa | |
| tert-butyl 11-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undecane-8-carboxylate | - |
Sus scrofa | |
| tert-butyl 4-(5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperidine-1-carboxylate | IC50: 0.000047 mM | Sus scrofa | |
| tert-butyl 4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-6,8,10-trioxo-2,7,9-triazaspiro[4.5]decane-2-carboxylate | IC50: 0.000128 mM | Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TACE | - |
Sus scrofa |
| tumor necrosis factor-alpha converting enzyme | - |
Sus scrofa |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000002 | - |
IC50: 0.000002 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[4-(methylsulfonyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide | |
| 0.000005 | - |
- |
Sus scrofa | N-[[5-(4-acetylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000005 | - |
IC50: 0.000005 mM | Sus scrofa | N-[[5-(4-acetylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000007 | - |
- |
Sus scrofa | N-([5-[4-(1-methylethyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000007 | - |
IC50: 0.000007 mM | Sus scrofa | N-([5-[4-(1-methylethyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.00001 | - |
IC50: 0.00001 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[4-(pyridin-3-ylcarbonyl)piperazin-1-yl]hexahydropyrimidin-5-yl]methyl)benzamide | |
| 0.000013 | - |
- |
Sus scrofa | tert-butyl (5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)carbamate | |
| 0.000013 | - |
IC50: 0.000013 mM | Sus scrofa | tert-butyl (5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)carbamate | |
| 0.000013 | - |
IC50: 0.000013 mM | Sus scrofa | N-([5-[1-(2,2-dimethylpropanoyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000014 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[[2,4,6-trioxo-5-(4-phenylpiperazin-1-yl)hexahydropyrimidin-5-yl]methyl]benzamide | |
| 0.000014 | - |
IC50: 0.000014 mM | Sus scrofa | N-[[5-(4-benzylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000016 | - |
- |
Sus scrofa | N-[(5-ethyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000016 | - |
IC50: 0.000016 mM | Sus scrofa | N-[(5-ethyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000018 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-phenylhexahydropyrimidin-5-yl)methyl]benzamide | |
| 0.000018 | - |
IC50: 0.000018 mM | Sus scrofa | N-[(5-benzyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000019 | - |
- |
Sus scrofa | N-[[5-(1-methylethyl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000019 | - |
IC50: 0.000019 mM | Sus scrofa | N-[[5-(1-methylethyl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000024 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-7,9-diazaspiro[4.5]dec-1-yl)benzamide | |
| 0.000024 | - |
IC50: 0.000024 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-7,9-diazaspiro[4.5]dec-1-yl)benzamide | |
| 0.000026 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]benzamide | |
| 0.000026 | - |
IC50: 0.000026 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]benzamide | |
| 0.000029 | - |
IC50: 0.000029 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-([5-[1-(methylsulfonyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)benzamide | |
| 0.000029 | - |
IC50: 0.000029 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[6,8,10-trioxo-2-(pyridin-3-ylcarbonyl)-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide | |
| 0.000029 | - |
IC50: 0.000029 mM | Sus scrofa | N-([5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000031 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-2-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide | |
| 0.000031 | - |
IC50: 0.000031 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-([2,4,6-trioxo-5-[1-(tetrahydro-2H-pyran-4-yl)piperidin-4-yl]hexahydropyrimidin-5-yl]methyl)benzamide | |
| 0.000036 | - |
IC50: 0.000036 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[2-(methylsulfonyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]benzamide | |
| 0.000044 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-2-oxa-7,9-diazaspiro[4.5]dec-4-yl)benzamide | |
| 0.000044 | - |
IC50: 0.000044 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(6,8,10-trioxo-2-oxa-7,9-diazaspiro[4.5]dec-4-yl)benzamide | |
| 0.000047 | - |
- |
Sus scrofa | tert-butyl 4-(5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperidine-1-carboxylate | |
| 0.000047 | - |
IC50: 0.000047 mM | Sus scrofa | tert-butyl 4-(5-[[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]methyl]-2,4,6-trioxohexahydropyrimidin-5-yl)piperidine-1-carboxylate | |
| 0.000052 | - |
- |
Sus scrofa | N-([5-[1-(1-methylethyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000052 | - |
IC50: 0.000052 mM | Sus scrofa | N-([5-[1-(1-methylethyl)piperidin-4-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000055 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-piperidin-4-ylhexahydropyrimidin-5-yl)methyl]benzamide | |
| 0.000055 | - |
- |
Sus scrofa | N-(8-acetyl-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undec-11-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000055 | - |
IC50: 0.000055 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[(2,4,6-trioxo-5-piperidin-4-ylhexahydropyrimidin-5-yl)methyl]benzamide | |
| 0.000055 | - |
IC50: 0.000055 mM | Sus scrofa | N-(2-acetyl-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000057 | - |
- |
Sus scrofa | N-[[5-(1-methylpiperidin-4-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000057 | - |
IC50: 0.000057 mM | Sus scrofa | N-[[5-(1-methylpiperidin-4-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000058 | - |
- |
Sus scrofa | N-[[5-(4-methylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000058 | - |
IC50: 0.000058 mM | Sus scrofa | N-[[5-(4-methylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000062 | - |
- |
Sus scrofa | N-([5-[4-(5-amino-8-carbamimidamido-4-oxooctyl)piperazin-1-yl]-2,4,6-trioxohexahydropyrimidin-5-yl]methyl)-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000062 | - |
IC50: 0.000062 mM | Sus scrofa | N-[[5-(4-ethynylpiperazin-1-yl)-2,4,6-trioxohexahydropyrimidin-5-yl]methyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000111 | - |
IC50: 0.000111 mM | Sus scrofa | N-[2-(2,2-dimethylpropanoyl)-6,8,10-trioxo-2,7,9-triazaspiro[4.5]dec-4-yl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide | |
| 0.000128 | - |
- |
Sus scrofa | tert-butyl 11-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-1,3,5-trioxo-2,4,8-triazaspiro[5.5]undecane-8-carboxylate | |
| 0.000128 | - |
IC50: 0.000128 mM | Sus scrofa | tert-butyl 4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-6,8,10-trioxo-2,7,9-triazaspiro[4.5]decane-2-carboxylate | |
| 0.000138 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(1,3,5-trioxo-2,4-diazaspiro[5.5]undec-7-yl)benzamide | |
| 0.000138 | - |
IC50: 0.000138 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(1,3,5-trioxo-2,4-diazaspiro[5.5]undec-7-yl)benzamide | |
| 0.0008 | - |
- |
Sus scrofa | 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-oxopropyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.0008 | - |
IC50: 0.0008 mM | Sus scrofa | 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-oxopropyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.00103 | - |
- |
Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.00103 | - |
IC50: 0.00103 mM | Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.0013 | - |
- |
Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.0013 | - |
IC50: 0.0013 mM | Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]phenoxy]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.0022 | - |
- |
Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.0022 | - |
IC50: 0.0022 mM | Sus scrofa | 5-methyl-5-[4-[(2-methylquinolin-4-yl)methoxy]benzyl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.00236 | - |
- |
Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)(pyridin-4-yl)methyl]benzamide | |
| 0.00236 | - |
IC50: 0.00236 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)(pyridin-4-yl)methyl]benzamide | |
| 0.011 | - |
- |
Sus scrofa | 5-methyl-5-[(2E)-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl]pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.011 | - |
IC50: 0.011 mM | Sus scrofa | 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]prop-2-en-1-yl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.012 | - |
- |
Sus scrofa | N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-3-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)propanamide | |
| 0.012 | - |
IC50: 0.012 mM | Sus scrofa | N-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)acetamide | |
| 0.049 | - |
- |
Sus scrofa | 5-methyl-5-(2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.049 | - |
IC50: 0.049 mM | Sus scrofa | 5-methyl-5-(2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]ethyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.1 | - |
IC50 above 0.1 mM | Sus scrofa | 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]propyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.1 | - |
IC50 above 0.1 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)benzamide | |
| 0.1 | - |
IC50 above 0.1 mM | Sus scrofa | 2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]acetamide | |
| 0.1 | - |
IC50: above 0.1 mM | Sus scrofa | 5-methyl-5-(3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]propyl)pyrimidine-2,4,6(1H,3H,5H)-trione | |
| 0.1 | - |
IC50: above 0.1 mM | Sus scrofa | 4-[(2-methylquinolin-4-yl)methoxy]-N-(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)benzamide | |
| 0.1 | - |
IC50: above 0.1 mM | Sus scrofa | 2-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-N-[(5-methyl-2,4,6-trioxohexahydropyrimidin-5-yl)methyl]acetamide | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
