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Literature summary for 3.4.24.86 extracted from

  • Mohan, M.J.; Seaton, T.; Mitchell, J.; Howe, A.; Blackburn, K.; Burkhart, W.; Moyer, M.; Patel, I.; Waitt, G.M.; Becherer, J.D.; Moss, M.L.; Milla, M.E.
    The tumor necrosis factor-alpha converting enzyme (TACE): A unique metalloproteinase with highly defined substrate selectivity (2002), Biochemistry, 41, 9462-9469.
    View publication on PubMed
Search for more literature for 3.4.24.86

Application

Application Comment Organism
medicine targeting this key enzyme for therapeutic intervention in inflammatory diseases, cancer and AIDS Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-
membrane
-
 Homo sapiens 16020
-
microsome
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Mus musculus
Zn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 MonoMac 6 cells
-
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
75kDaTNFR2 + H2O
-
 Homo sapiens ?
-
 ?
beta-amyloid precursor protein + H2O
-
 Mus musculus ?
-
 ?
beta-amyloid precursor protein + H2O Alzheimer amyloid precursor protein Homo sapiens ?
-
 ?
beta-amyloid precursor protein + H2O APP Homo sapiens ?
-
 ?
c-KLR + H2O
-
 Homo sapiens ?
-
 ?
CD30 + H2O
-
 Homo sapiens ?
-
 ?
cellular prion protein PrPc + H2O
-
 Homo sapiens ?
-
 ?
fractalkine + H2O FK, CX3CL1 Homo sapiens ?
-
 ?
GHR + H2O
-
 Homo sapiens ?
-
 ?
interleukin-6-receptor + H2O
-
 Homo sapiens ?
-
 ?
KL-1 + H2O
-
 Homo sapiens ?
-
 ?
L-selectin + H2O
-
 Mus musculus ?
-
 ?
L-selectin + H2O
-
 Homo sapiens ?
-
 ?
macrophage colony-stimulating factor receptor M-CSFR + H2O
-
 Homo sapiens ?
-
 ?
additional information
-
 Mus musculus ?
-
 ?
additional information 4-dinitrophenyl)-L-2,3-diaminopropionyl diaminopropionic amide-PChaGC(Me)HK(NMA)-NH2 is not cleaved at all by TACE Homo sapiens ?
-
 ?
notch 1 receptor + H2O
-
 Homo sapiens ?
-
 ?
p55 TNFR1 + H2O
-
 Mus musculus ?
-
 ?
p55 TNFR1 + H2O
-
 Homo sapiens ?
-
 ?
proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
RANKL + ?
-
 Homo sapiens ?
-
 ?
TRANCE + H2O
-
 Homo sapiens ?
-
 ?
transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?