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Literature summary for 3.4.24.86 extracted from

  • Vincent, B.; Paitel, E.; Saftig, P.; Frobert, Y.; Hartmann, D.; De Strooper, B.; Grassi, J.; Lopez-Perez, E.; Checler, F.
    The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein (2001), J. Biol. Chem., 276, 37743-37746.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phorbol ester
-
Mus musculus
phorbol ester
-
Homo sapiens

Application

Application Comment Organism
medicine putative cellular targets of a therapeutic strategy in neurodegenerative prion diseases Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
human embryonic kidney 293 transfectants overexpressing TACE Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Homo sapiens
1,10-phenanthroline
-
Mus musculus
BB3103
-
Homo sapiens
TAPI
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
HEK293 cells
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
embryo
-
Mus musculus
-
embryo
-
Homo sapiens
-
fibroblast
-
Mus musculus
-
fibroblast
-
Homo sapiens
-
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cellular prion protein PrPc + H2O
-
Homo sapiens ?
-
?
proTNF-alpha + H2O
-
Mus musculus soluble TNF-alpha
-
?
proTNF-alpha + H2O
-
Homo sapiens soluble TNF-alpha
-
?
transforming growth factor alpha + H2O
-
Mus musculus ?
-
?
transforming growth factor alpha + H2O
-
Homo sapiens ?
-
?