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Literature summary for 3.4.24.86 extracted from
- Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine (2001), J. Biol. Chem., 276, 44622-44626.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TAPI-2 | hydroxamate-based inhibitor of matrix metalloproteases that has high activity against TACE | Homo sapiens |  |
| TAPI-2 | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Mus musculus | 9986 | - |
| cell surface | - |
Homo sapiens | 9986 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
mouse | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelium | - |
Mus musculus | - |
| endothelium | - |
Homo sapiens | - |
| epithelium | - |
Homo sapiens | - |
| fibroblast | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| neuron | - |
Mus musculus | - |
| neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fractalkine + H2O | FK, CX3CL1 | Homo sapiens | ? | - |
? | |
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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