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Literature summary for 3.4.24.86 extracted from
- Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzyme (2000), J. Biol. Chem., 275, 14598-14607.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lipopolysaccharide | - |
Homo sapiens |  |
| phorbol 12-myristate-13-acetate | PMA | Homo sapiens | |
| phorbol ester | - |
Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinantly expressed human TACE in plasmid transfected chinese hamster ovary cells | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| surface-biotinylated TACE is stable in Jurkat cells with a half-life of at least 8h | Homo sapiens |
| TACE appears quite stable in untreated cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| IC-3 | protects TACE from degradation by inhibiting either TACE itself or another metalloprotease | Homo sapiens | |
| TIMP-3 | tissue inhibitor of metalloproteases-3, CAS: 147783-68-4, 171039-15-9, 13037-60-4 | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
| cytoplasm | - |
Homo sapiens | 5737 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Homo sapiens | - |
HeLa cells | - |
| Homo sapiens | - |
human monocytic cell line THP-1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| monocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | alpha-secretase processing | Homo sapiens | ? | - |
? | |
| L-selectin + H2O | regulates plasma membrane composition and releases soluble signaling molecules and receptors from cells | Homo sapiens | ? | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sheddase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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