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Literature summary for 3.4.24.86 extracted from

  • Brou, C.; Logeat, F.; Gupta, N.; Bessia, C.; LeBail, O.; Doedens, J.R.; Cumano, A.; Roux, P.; Black, R.A.; Israel, A.
    A novel proteolytic cleavage involved in notch signaling: the role of the disintegrin-metalloprotease TACE (2000), Mol. Cell, 5, 207-216.
    View publication on PubMed
Search for more literature for 3.4.24.86

Application

Application Comment Organism
medicine tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor, activating TACE by pharmacological manipulation might prove beneficial in Alzheimer's disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
bone marrow cultures infected with a retrovirus expressing murine TACE cDNA Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens
1,10-phenanthroline
-
 Mus musculus
dithiothreitol
-
 Homo sapiens
EDTA
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Homo sapiens
-
 HeLa cells
-
Mus musculus
-
 mouse
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Mus musculus
-
bone marrow
-
 Homo sapiens
-
fibroblast
-
 Mus musculus
-
fibroblast
-
 Homo sapiens
-
monocyte
-
 Mus musculus
-
monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proTNF-alpha + H2O
-
 Mus musculus soluble TNF-alpha
-
 ?
proTNF-alpha + H2O
-
 Homo sapiens soluble TNF-alpha
-
 ?
transforming growth factor alpha + H2O
-
 Mus musculus ?
-
 ?
transforming growth factor alpha + H2O
-
 Homo sapiens ?
-
 ?