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Literature summary for 3.4.24.86 extracted from
- TNFalpha processing enzyme inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal injury in rats (1998), Aliment. Pharmacol. Ther., 12, 1139-1153.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | TACE inhibitors prevent TNFalpha release and protect against TNFalpha-mediated disease | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BB3103 | - |
Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus |  |
| TAPI-2 | - |
Mus musculus | |
| TAPI-2 | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
mouse | - |
| Rattus norvegicus | - |
rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric mucosa | - |
Rattus norvegicus | - |
| macrophage | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Rattus norvegicus | ? | - |
? | |
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