Any feedback?
Literature summary for 3.4.24.85 extracted from
- New insights into S2P signaling cascades: regulation, variation and conservation (2010), Protein Sci., 19, 2015-2030.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | SpoIVFB is held inactive by two other integral-membrane proteins, SpoIVFA and BofA | Bacillus subtilis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | - |
Escherichia coli | - |
- |
| cytoplasmic membrane | - |
Mycobacterium tuberculosis | - |
- |
| cytoplasmic membrane | - |
Caulobacter vibrioides | - |
- |
| cytoplasmic membrane | - |
Cryptococcus neoformans | - |
- |
| cytoplasmic membrane | - |
Streptococcus uberis | - |
- |
| Golgi apparatus | - |
Bacillus subtilis | 5794 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| Golgi apparatus | - |
Enterococcus faecalis | 5794 | - |
| membrane | - |
Pseudomonas aeruginosa | 16020 | - |
| membrane | - |
Bordetella bronchiseptica | 16020 | - |
| membrane | periplasmic | Mycobacterium tuberculosis | 16020 | - |
| membrane | periplasmic | Streptococcus uberis | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | a zinc metalloprotease | Bacillus subtilis |  |
| Zn2+ | a zinc metalloprotease | Escherichia coli | |
| Zn2+ | a zinc metalloprotease | Homo sapiens | |
| Zn2+ | a zinc metalloprotease | Pseudomonas aeruginosa | |
| Zn2+ | a zinc metalloprotease | Bordetella bronchiseptica | |
| Zn2+ | a zinc metalloprotease | Enterococcus faecalis | |
| Zn2+ | a zinc metalloprotease | Mycobacterium tuberculosis | |
| Zn2+ | a zinc metalloprotease | Caulobacter vibrioides | |
| Zn2+ | a zinc metalloprotease | Cryptococcus neoformans | |
| Zn2+ | a zinc metalloprotease | Streptococcus uberis | |
| Zn2+ | a zinc metalloprotease | Methanocaldococcus jannaschii | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATF6 protein + H2O | Homo sapiens | - |
? | - |
? | |
| cAD1 protein + H2O | Enterococcus faecalis | - |
? | - |
? | |
| cCF10 protein + H2O | Enterococcus faecalis | - |
? | - |
? | |
| cPD1 protein + H2O | Enterococcus faecalis | - |
? | - |
? | |
| CREBH protein + H2O | Homo sapiens | - |
? | - |
? | |
| FtsL protein + H2O | Bacillus subtilis | - |
? | - |
? | |
| HurR protein + H2O | Bordetella bronchiseptica | - |
? | - |
? | |
| iAD1 protein + H2O | Enterococcus faecalis | - |
? | - |
? | |
| iCF10 protein + H2O | Enterococcus faecalis | - |
? | - |
? | |
| MtuA protein + H2O | Streptococcus uberis | - |
? | - |
? | |
| MucA protein + H2O | Pseudomonas aeruginosa | - |
? | - |
? | |
| OASIS protein + H2O | Homo sapiens | - |
? | - |
? | |
| PBP3 protein + H2O | Mycobacterium tuberculosis | - |
? | - |
? | |
| PodJ protein + H2O | Caulobacter vibrioides | - |
? | - |
? | |
| pro-deltaK protein + H2O | Bacillus subtilis | - |
deltaK protein + N-terminal fragment of 20 amino acids of pro-deltaK protein | - |
? | |
| RseA protein + H2O | Escherichia coli | - |
? | - |
? | |
| RsiW protein + H2O | Bacillus subtilis | - |
? | - |
? | |
| Sre1 protein + H2O | Cryptococcus neoformans | - |
? | - |
? | |
| sterol regulatory element binding protein + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Bordetella bronchiseptica | - |
- |
- |
| Caulobacter vibrioides | - |
- |
- |
| Cryptococcus neoformans | - |
- |
- |
| Enterococcus faecalis | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Methanocaldococcus jannaschii | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Streptococcus uberis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATF6 protein + H2O | - |
Homo sapiens | ? | - |
? | |
| cAD1 protein + H2O | - |
Enterococcus faecalis | ? | - |
? | |
| cCF10 protein + H2O | - |
Enterococcus faecalis | ? | - |
? | |
| cPD1 protein + H2O | - |
Enterococcus faecalis | ? | - |
? | |
| CREBH protein + H2O | - |
Homo sapiens | ? | - |
? | |
| FtsL protein + H2O | - |
Bacillus subtilis | ? | - |
? | |
| HurR protein + H2O | - |
Bordetella bronchiseptica | ? | - |
? | |
| iAD1 protein + H2O | - |
Enterococcus faecalis | ? | - |
? | |
| iCF10 protein + H2O | - |
Enterococcus faecalis | ? | - |
? | |
| MtuA protein + H2O | - |
Streptococcus uberis | ? | - |
? | |
| MucA protein + H2O | - |
Pseudomonas aeruginosa | ? | - |
? | |
| OASIS protein + H2O | - |
Homo sapiens | ? | - |
? | |
| PBP3 protein + H2O | - |
Mycobacterium tuberculosis | ? | - |
? | |
| PodJ protein + H2O | - |
Caulobacter vibrioides | ? | - |
? | |
| pro-deltaK protein + H2O | - |
Bacillus subtilis | deltaK protein + N-terminal fragment of 20 amino acids of pro-deltaK protein | - |
? | |
| RseA protein + H2O | - |
Escherichia coli | ? | - |
? | |
| RsiW protein + H2O | - |
Bacillus subtilis | ? | - |
? | |
| Sre1 protein + H2O | - |
Cryptococcus neoformans | ? | - |
? | |
| sterol regulatory element binding protein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EcfE | - |
Escherichia coli |
| Eep | - |
Enterococcus faecalis |
| Eep | - |
Streptococcus uberis |
| HurP | - |
Bordetella bronchiseptica |
| MmpA | - |
Caulobacter vibrioides |
| MucP | - |
Pseudomonas aeruginosa |
| RasP | - |
Bacillus subtilis |
| RseP | - |
Escherichia coli |
| Rv2869c | - |
Mycobacterium tuberculosis |
| S2P | - |
Bacillus subtilis |
| S2P | - |
Escherichia coli |
| S2P | - |
Homo sapiens |
| S2P | - |
Pseudomonas aeruginosa |
| S2P | - |
Bordetella bronchiseptica |
| S2P | - |
Enterococcus faecalis |
| S2P | - |
Mycobacterium tuberculosis |
| S2P | - |
Caulobacter vibrioides |
| S2P | - |
Cryptococcus neoformans |
| S2P | - |
Streptococcus uberis |
| S2P | - |
Methanocaldococcus jannaschii |
| site-2 protease | - |
Bacillus subtilis |
| site-2 protease | - |
Escherichia coli |
| site-2 protease | - |
Homo sapiens |
| site-2 protease | - |
Pseudomonas aeruginosa |
| site-2 protease | - |
Bordetella bronchiseptica |
| site-2 protease | - |
Enterococcus faecalis |
| site-2 protease | - |
Mycobacterium tuberculosis |
| site-2 protease | - |
Caulobacter vibrioides |
| site-2 protease | - |
Cryptococcus neoformans |
| site-2 protease | - |
Streptococcus uberis |
| site-2 protease | - |
Methanocaldococcus jannaschii |
| SPOIVFB | - |
Bacillus subtilis |
| Stp1 | - |
Cryptococcus neoformans |
| YaeL | - |
Escherichia coli |
| YluC | - |
Bacillus subtilis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | HurP is essential for heme-dependent induction of bhuR and downstream genes | Bordetella bronchiseptica |
| physiological function | the enzyme is involved in activation of the crucial membrane-associated transcription factors deltaK during sporulation | Bacillus subtilis |
| physiological function | the enzyme is involved in the feedback regulation of sterol and fatty acid synthesis and uptake by controlling the activity of transcription factors, sterol regulatory element binding proteins. Through the S2P cascade, the cholesterol feedback pathway in humans is stringently regulated | Homo sapiens |
| physiological function | the enzyme is involved in the production of pheromone cAD1, cPD1, and cCF10, and inhibitor peptide iAD1 and iCF10.The enzyme processes the sex pheromone and inhibitor precursors as they pass through the cell membrane | Enterococcus faecalis |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
