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Literature summary for 3.4.24.85 extracted from

  • Ye, J.; Davé, U.; Grishin, N.; Goldstein, J.; Brown, M.
    Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease (2000), Proc. Natl. Acad. Sci. USA, 97, 5123-5128.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.85

Organism

Organism UniProt Comment Textmining
Homo sapiens O43462 s2p cloned
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SREBP asparagine-495 and proline-496 seem to be necessary for cleavage by S2P, and it is conserved in all known SREBPs, the movement of the NP sequence within the transmembrane domain does not eliminate cleavage, nor does it change the site of cleavage Homo sapiens ?
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