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Literature summary for 3.4.24.85 extracted from
- Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs (1997), Mol. Cell, 1, 47-57.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in CHO cell line | Cricetulus griseus |
| expressed in M19 cell line | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | M19 mutant cell line of CHO-K1 cells with no s2p activity | Cricetulus griseus |
| additional information | mutants in any of the histidines for phenylalanine or glutamic acid for alanine of the consensus metal-binding site abolished activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cricetulus griseus | O54862 | Chinese hamster, s2p cloned | - |
| Homo sapiens | O43462 | s2p cloned | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | cDNA library | Homo sapiens | - |
| ovary cell line | CHO-7 and M19 S2P deficient cell lines | Cricetulus griseus | - |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Zn | zinc metalloprotease | Homo sapiens |  |
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Release 2023.1 (January 2023)
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