Literature summary for 3.4.24.84 extracted from

Rivas, D.; Li, W.; Akter, R.; Henderson, J.E.; Duque, G.
Accelerated features of age-related bone loss in zmpste24 metalloproteinase-deficient mice (2009), J. Gerontol. A Biol. Sci. Med. Sci., 64, 1015-1024.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

General Information

General Information	Comment	Organism
malfunction	defective prelamin A processing induces accelerated features of age-related bone loss including lower osteoblast and osteocyte numbers and higher levels of marrow adipogenesis	Mus musculus
physiological function	Zmpste24-null progeroid mice exhibit nuclear lamina defects and accumulate unprocessed prelamin A. Defective prelamin A processing induces accelerated features of age-related bone loss including lower osteoblast and osteocyte numbers and higher levels of marrow adipogenesis. There is a significant loss in trabecular and cortical bone between the Zmpste24 -/- mice compared with the wild-type controls. At 3 months of age, Zmpste24 -/- mice show a significant decrease in bone volume/tissue volume, trabecular thickness, and trabecular number compared with their wild-type littermates	Mus musculus

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Release 2023.1 (January 2023)