Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lopinavir | HIV protease inhibitors inhibit ZMPSTE24, leading to an accumulation of farnesyl-prelamin A. The inhibition of ZMPSTE24 by HIV protease inhibitors could play a role in the side effects of these drugs | Mus musculus | |
tipranavir | HIV protease inhibitors inhibit ZMPSTE24, leading to an accumulation of farnesyl-prelamin A. The inhibition of ZMPSTE24 by HIV protease inhibitors could play a role in the side effects of these drugs | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
recombinantly expressed in yeast | - |
Synonyms | Comment | Organism |
---|---|---|
Zmpste24 | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
- |
Mus musculus | tipranavir | |
0.0184 | - |
- |
Mus musculus | lopinavir |