Organism | UniProt | Comment | Textmining |
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Bacillus anthracis | - |
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General Information | Comment | Organism |
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physiological function | in mice treated with Anthrax lethal factor, serum lactate levels are reduced. Lethal factor inhibits the accumulation of hypoxia-inducible factor HIF-1alpha, a subunit of HIF-1, the master regulator directing cellular responses to hypoxia. The toxin has no effect on the transcription or protein turnover of HIF-1LPH, but inhibits HIF-1alpha translation. Lethal factor treatment diminishes phosphorylation of eIF4B, eIF4E, and rpS6, critical components of the intracellular machinery required for HIF-1alpha translation. Lethal factor treatment decreases the survival of hepatocyte cell lines grown in hypoxic conditions, an effect that is overcome by preinduction of HIF-1alpha | Bacillus anthracis |