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Literature summary for 3.4.24.83 extracted from
- Anthrax lethal factor activates K+ channels to induce IL-1beta secretion in macrophages (2011), J. Immunol., 186, 5236-5243.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus anthracis | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| anthrax lethal factor | - |
Bacillus anthracis |
| anthrax lethal toxin | - |
Bacillus anthracis |
| LeTx | - |
Bacillus anthracis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | anthrax lethal toxin is a virulence factor of Bacilillus anthracis that is a bivalent toxin, containing lethal factor and protective Ag proteins, which causes cytotoxicity and altered macrophage function. Anthrax lethal toxin exposure results in early K+ efflux from macrophages associated with caspase-1 activation and increased interleukin-1beta release | Bacillus anthracis |
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Release 2023.1 (January 2023)
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