Literature summary for 3.4.24.83 extracted from

Abrami, L.; Kunz, B.; van der Goot, F.G.
Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake (2010), Proc. Natl. Acad. Sci. USA, 107, 1420-1424.

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Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
MEK1 + H2O	i.e. signal-regulated kinase activator kinase	Bacillus anthracis	?	-	?

General Information

General Information	Comment	Organism
physiological function	the anthrax toxin triggers tyrosine phosphorylation of its own receptors, capillary morphogenesis gene 2 and tumor endothelial marker 8, which is required for efficient toxin uptake. Phosphorylation of the receptors is dependent on src-like kinases, which are activated upon toxin binding. src-Dependent phosphorylation of the receptor is required for its subsequent ubiquitination, which in turn is required for clathrin-mediated endocytosis. Uptake of the anthrax toxin and processing of the lethal factor substrate MEK1 are inhibited by silencing of src and fyn, as well as in src and fyn knockout cells	Bacillus anthracis

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Release 2023.1 (January 2023)