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Literature summary for 3.4.24.83 extracted from

  • Kocer, S.S.; Matic, M.; Ingrassia, M.; Walker, S.G.; Roemer, E.; Licul, G.; Simon, S.R.
    Effects of anthrax lethal toxin on human primary keratinocytes (2008), J. Appl. Microbiol., 105, 1756-1767.
    View publication on PubMed
Search for more literature for 3.4.24.83

Application

Application Comment Organism
molecular biology primary keratinocytes are resistant to LeTx cytotoxicity, and MEK cleavage does not correlate with LeTx cytotoxicity. LeTx is considered as an anti-inflammatory agent, however it upregulates RANTES Bacillus anthracis

Protein Variants

Protein Variants Comment Organism
additional information effects of anthrax lethal toxin on human primary keratinocytes are investigated. Cells are resistant to LeTx-triggered cytotoxicity, even though all the MEK (MEK1 through 7), except MEK5, are cleaved in these cells. Over the 24 h time course of the study, the levels of two pro-inflammatory molecules, interleukin-6 and granulocyte-macrophage colony stimulating factor (GM-CSF), decline, but the production of RANTES, a known chemoattractant for multiple types of immune cells, increases Bacillus anthracis

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
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-
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitogen-activated protein kinase kinase 1 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
mitogen-activated protein kinase kinase 2 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
mitogen-activated protein kinase kinase 3 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
mitogen-activated protein kinase kinase 4 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
mitogen-activated protein kinase kinase 6 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?
mitogen-activated protein kinase kinase 7 + H2O all but one of the mitogen-activated protein kinase kinases (MEK) are cleaved within 3 h, and the cleavage of MEKs in keratinocytes leads to their subsequent proteasome-mediated degradation at different rates Bacillus anthracis ?
-
 ?

Synonyms

Synonyms Comment Organism
anthrax lethal toxin
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 Bacillus anthracis
LeTx
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 Bacillus anthracis