Literature summary for 3.4.24.83 extracted from

deCathelineau, A.M.; Bokoch, G.M.
Inactivation of rho GTPases by statins attenuates anthrax lethal toxin activity (2009), Infect. Immun., 77, 348-359.

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Application

Application	Comment	Organism
medicine	the use of drugs capable of inhibiting Rho GTPase activity, such as statins, may provide a means to attenuate intoxication during Bacillus anthracis infection	Bacillus anthracis

Inhibitors

Inhibitors	Comment	Organism	Structure
fluvastatin	statins attenuate lethal factor action action. statin treatment maintains macrophage cell viability above 60% of untreated control cells even after 9 h of lethal toxin treatment. Statins decrease mitogen-activated protein kinase cleavage	Bacillus anthracis
mevastatin	statins attenuate lethal factor action action. statin treatment maintains macrophage cell viability above 60% of untreated control cells even after 9 h of lethal toxin treatment. Statins decrease mitogen-activated protein kinase cleavage	Bacillus anthracis
additional information	statin-mediated effects on lethal toxin action are attributable to disruption of Rho GTPases. The Rho GTPase-inactivating toxin, toxin B, does not significantly affect lethal toxin binding or internalization, suggesting that the Rho GTPases regulate trafficking and/or localization of lethal toxin once internalized	Bacillus anthracis
simvastatin	statins attenuate lethal factor action action. statin treatment maintains macrophage cell viability above 60% of untreated control cells even after 9 h of lethal toxin treatment. Statins decrease mitogen-activated protein kinase cleavage	Bacillus anthracis

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
mitogen-activated protein kinase + H2O	-	Bacillus anthracis	?	-	?

Synonyms

Synonyms	Comment	Organism
anthrax lethal toxin	-	Bacillus anthracis

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Release 2023.1 (January 2023)