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Literature summary for 3.4.24.83 extracted from

  • Chou, P.J.; Newton, C.A.; Perkins, I.; Friedman, H.; Klein, T.W.
    Suppression of dendritic cell activation by anthrax lethal toxin and edema toxin depends on multiple factors including cell source, stimulus used, and function tested (2008), DNA Cell Biol., 27, 637-648.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
molecular biology toxin effects of lethal toxin and edema toxin of Bacillus anthracis in bone marrow dendritic cells stimulated with either LPS or Legionella pneumophila are analysed. Lethal toxin, not ET, is more toxic for cells from BALB/c mice than from C57BL/6 as measured by 7-AAD uptake. Results support the conclusion that lethal toxin and edema toxin are not uniformly suppressive of dendritic cell function but rather modulate function up or down depending on variables such as the function tested, the microbial stimulus used, and the genetic variation in innate immune response mechanisms in the host cell Bacillus anthracis

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
anthrax lethal toxin
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 Bacillus anthracis
lethal toxin
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 Bacillus anthracis