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Literature summary for 3.4.24.83 extracted from

  • Fink, S.L.; Bergsbaken, T.; Cookson, B.T.
    Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms (2008), Proc. Natl. Acad. Sci. USA, 105, 4312-4317.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.83

Protein Variants

Protein Variants Comment Organism
E678C catalytically inactive Bacillus anthracis

Inhibitors

Inhibitors Comment Organism Structure
additional information Ca2+-free medium completely prevents mitogen-activated protein kinase kinase 3 proteolysis in anthrax lethal toxin-treated macrophages Bacillus anthracis
NH4Cl blocks mitogen-activated protein kinase kinase 3 proteolysis in anthrax lethal toxin-treated macrophages Bacillus anthracis
verapamil blocks mitogen-activated protein kinase kinase 3 proteolysis in anthrax lethal toxin-treated macrophages Bacillus anthracis

Organism

Organism UniProt Comment Textmining
Bacillus anthracis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitogen-activated protein kinase kinase 1 + H2O
-
 Bacillus anthracis ?
-
 ?
mitogen-activated protein kinase kinase 3 + H2O
-
 Bacillus anthracis ?
-
 ?
additional information participates in the activation of caspase-1 Bacillus anthracis ?
-
 ?

Synonyms

Synonyms Comment Organism
lethal factor
-
 Bacillus anthracis