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Literature summary for 3.4.24.82 extracted from

  • Ren, P.; Hughes, M.; Krishnamoorthy, S.; Zou, S.; Zhang, L.; Wu, D.; Zhang, C.; Curci, J.A.; Coselli, J.S.; Milewicz, D.M.; LeMaire, S.A.; Shen, Y.H.
    Critical role of ADAMTS-4 in the development of sporadic aortic aneurysm and dissection in mice (2017), Sci. Rep., 7, 12351 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.82

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the enzyme translocates to the nucleus of apoptotic cells Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
poly-ADP ribose polymerase-1 + H2O Mus musculus
-
 ?
-
 ?
versican + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8BNJ2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Mus musculus
-
smooth muscle cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
poly-ADP ribose polymerase-1 + H2O
-
 Mus musculus ?
-
 ?
versican + H2O
-
 Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 68000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
a disintegrin-like and metalloproteinase with thrombospondin motifs-4
-
 Mus musculus
ADAMTS-4
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is increased in mice with aortic aneurysm and dissection up

General Information

General Information Comment Organism
malfunction aortas in enzyme-deficient mice show reduced elastic fibre destruction, versican degradation, macrophage infiltration, and apoptosis. Enzyme deficiency in mice partially prevents aortic destruction and proteoglycan degradation, decreases inflammatory cell infiltration in the aorta, and reduces aortic apoptosis Mus musculus
physiological function the enzyme contributes to aortic destruction and sporadic aortic aneurysm and dissection development and is directly involved in smooth muscle cell apoptosis Mus musculus