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Literature summary for 3.4.24.82 extracted from

  • Fowkes, M.M.; Lim, N.H.
    Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants (2020), Methods Mol. Biol., 2043, 75-91 .
    View publication on PubMed
Search for more literature for 3.4.24.82

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
 5-carboxyfluorescein-Ala-Glu-Leu-Gln-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys-N,N,N',N'-tetramethyl-6-carboxyrhodamine at pH 7.5 and 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aggrecan + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75173
-
-

Purification (Commentary)

Purification (Comment) Organism
anti-FLAG M2 affinity gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-carboxyfluorescein-Ala-Glu-Leu-Gln-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys-N,N,N',N'-tetramethyl-6-carboxyrhodamine + H2O
-
 Homo sapiens 5-carboxyfluorescein-Ala-Glu + Leu-Gln-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lys-N,N,N',N'-tetramethyl-6-carboxyrhodamine
-
 ?
aggrecan + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4
-
 Homo sapiens
ADAMTS-4
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is involved in the maintenance of cartilage extracellular matrix Homo sapiens