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Literature summary for 3.4.24.82 extracted from
- ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis (2011), J. Cell. Biochem., 112, 3507-3514.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | the optimum NaCl concentration for aggrecan degradation is between 12.5 and 50 mM | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | ADAMTS-4 is a key enzyme in osteoarthritis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| TIMP-3 | - |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | Homo sapiens | - |
fragments of aggrecan | - |
? | |
| brevican + H2O | Homo sapiens | - |
fragments of brevican | - |
? | |
| carboxymethylated transferrin + H2O | Homo sapiens | - |
? | - |
? | |
| cartilage oligomeric matrix protein + H2O | Homo sapiens | - |
? | - |
? | |
| decorin + H2O | Homo sapiens | - |
? | - |
? | |
| fibromodulin + H2O | Homo sapiens | - |
? | - |
? | |
| versican V1 + H2O | Homo sapiens | - |
fragments of versican V1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan + H2O | - |
Homo sapiens | fragments of aggrecan | - |
? | |
| brevican + H2O | - |
Homo sapiens | fragments of brevican | - |
? | |
| carboxymethylated transferrin + H2O | - |
Homo sapiens | ? | - |
? | |
| cartilage oligomeric matrix protein + H2O | - |
Homo sapiens | ? | - |
? | |
| decorin + H2O | - |
Homo sapiens | ? | - |
? | |
| fibromodulin + H2O | - |
Homo sapiens | ? | - |
? | |
| versican V1 + H2O | - |
Homo sapiens | fragments of versican V1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS-4 | - |
Homo sapiens |
| aggrecanase 1 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9.5 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | interleukin-1 and TNF-alpha upregulate ADAMTS-4 mRNA expression | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAMTS-4 is responsible for aggrecan degradation during human articular cartilage destruction in vivo | Homo sapiens |
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