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Literature summary for 3.4.24.82 extracted from
- Anti-angiogenic properties of ADAMTS-4 in vitro (2012), Int. J. Exp. Pathol., 93, 70-77.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | ADAMTS-4 binds to vascular endothelial growth factor | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| a disintegrin and metalloproteinase with thrombospondin motifs-4 | - |
Homo sapiens |
| ADAMTS-4 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADAMTS-4 inhibits human dermal microvascular endothelial cells (HuDMEC) vascular endothelial growth factor-stimulated vascular endothelial growth factor receptor R2 phosphorylation in a dose-related manner to give a maximum of about 65% inhibition at and above 30 nM. ADAMTS-4 reduces HuDMEC differentiation and migration | Homo sapiens |
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Release 2023.1 (January 2023)
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